Ici, vous trouverez dans de courts articles sur les résultats et les derniers résultats de la recherche.
10:00-10.30 Clock - The awarding of the prize-Gunter-Speidel
The majority of neuroendocrine tumors (NET) of the gastro-intestinal tract is diagnosed at an advanced stage. Due to the presence of metastases (metastases), then a definitive cure of the disease is not usually possible. For this reason, the improvement of drug treatment of NET is a major goal of cancer research. A comprehensive knowledge of the origin and course of NETs represents an important prerequisite for the development of new and improved therapies.
Oxygen deficiency (technical term: hypoxia) is a central trait of various cancers, including by NETs. The detection of hypoxia in the tumor is often associated with a poor prognosis include due to a poor effect of chemotherapy in oxygen deficiency. The effect of hypoxia in tumors is mainly through the protein "hypoxia-inducible factor 1 (HIF-1)" taught. This factor leads to activation of different signaling pathways that promote tumor growth and reduce the effect of chemotherapy. As in various other cancers was also on the net, increased levels of HIF-1 can be detected. Our studies may suggest that inhibition of HIF-1 would result in a decrease in the malignant properties of NETs and improve the effectiveness of chemotherapy. In the proposed research project is now to the importance of HIF-1 for the emergence and progression of NETs using modern techniques in detail are examined. Here are to be identified through sophisticated methods such as the analysis of so-called expression profiles of HIF-1-dependent signals are analyzed as a possible new therapeutic targets. This analysis will provide information as to what extent HIF-1-inhibiting substances have an importance for the treatment of NETs.
The experimental work by Katja Freitag de Molina in the group of PD Dr. Thorsten Cramer in the Medical Department, Division of Gastroenterology and Hepatology: performed at the Campus Virchow-Klinikum of the Charité in Berlin (Director Prof. Dr. Bertram Wiedenmann). Special thanks is due here Mr. Gunter Speidel, without whose generous support the work in its current form would not have been possible.
Contact:
PD Dr. med. Thorsten Cramer
Charité Centrum 13
Medizinische Klinik m.S. Hepatologie und Gastroenterologie
Charité - Universitätsmedizin Berlin
Campus Virchow-Klinikum
Augustenburger Platz 1
13353 Berlin
Telefon: 030/450 553 022
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